GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BRCA | cis | rs4731120 | 1 | rs12666411 | chr7:123406061 | HYAL4 | chr7:123485223-123517529:+ | 0.3 | 4.27 | 2.17E-5 | Platelet count |
| BRCA | cis | rs4731120 | 1 | rs12667932 | chr7:123423923 | HYAL4 | chr7:123485223-123517529:+ | 0.28 | 4.09 | 4.62E-5 | Platelet count |
| BRCA | cis | rs4731120 | 1 | rs12668254 | chr7:123436850 | HYAL4 | chr7:123485223-123517529:+ | -0.23 | -3.75 | 0.000184 | Platelet count |
| BRCA | cis | rs4731120 | 1 | rs12670684 | chr7:123405942 | HYAL4 | chr7:123485223-123517529:+ | 0.29 | 4.24 | 2.45E-5 | Platelet count |
| BRCA | cis | rs4731120 | 1 | rs12671376 | chr7:123407146 | HYAL4 | chr7:123485223-123517529:+ | 0.29 | 4.11 | 4.2E-5 | Platelet count |
| BRCA | cis | rs4731120 | 1 | rs12671766 | chr7:123420010 | HYAL4 | chr7:123485223-123517529:+ | 0.28 | 4.09 | 4.62E-5 | Platelet count |
| BRCA | cis | rs1005390 | 1 | rs12672953 | chr7:150539695 | TMEM176A | chr7:150497854-150502208:+ | -0.15 | -3.42 | 0.000642 | Blood metabolite levels;Blood metabolite ratios |
| BRCA | cis | rs1005390 | 1 | rs12672953 | chr7:150539695 | TMEM176B | chr7:150488378-150498448:- | -0.16 | -3.63 | 0.000293 | Blood metabolite levels;Blood metabolite ratios |
| BRCA | cis | rs783540 | 1 | rs1267657 | chr15:83215251 | FAM154B | chr15:82555152-82577265:+ | -0.13 | -3.81 | 0.000146 | Schizophrenia |
| BRCA | cis | rs783540 | 1 | rs1267657 | chr15:83215251 | GOLGA6L9 | chr15:82711895-82731584:+;chr15 | -0.1 | -3.79 | 0.000162 | Schizophrenia |
| BRCA | cis | rs1499614 | 1 | rs1267817 | chr7:66110040 | CCT6P1 | chr7:65216092-65228661:+ | 0.32 | 6.71 | 3.15E-11 | Gout |
| BRCA | cis | rs1499614 | 1 | rs1267817 | chr7:66110040 | LOC493754 | chr7:65993446-66057363:- | 0.24 | 4.03 | 6.03E-5 | Gout |
| BRCA | cis | rs1499614 | 1 | rs1267818 | chr7:66107024 | CCT6P1 | chr7:65216092-65228661:+ | 0.32 | 6.82 | 1.54E-11 | Gout |
| BRCA | cis | rs1499614 | 1 | rs1267818 | chr7:66107024 | LOC493754 | chr7:65993446-66057363:- | 0.25 | 4.13 | 3.85E-5 | Gout |
| BRCA | cis | rs2243480 | 1 | rs1267820 | chr7:66050295 | CCT6P1 | chr7:65216092-65228661:+ | 0.32 | 6.69 | 3.59E-11 | Diabetic kidney disease |